For additional information about this model, please contact
M. Chagnon

Infectious Diseases
(Provided by Dr. Danielle Malo, Project Manager; Dr. Silvia Vidal and Dr. Philippe Gros, Organization and Planification Committee and colleagues)
McGill University Health Center for the Study of Host Resistance, McGill University
 
Description of services offered

The reference center for murine phenotyping in infectious diseases in Quebec has for objective to furnish clinical phenotyping (sick/healthy and intermediary evaluation of the infection levels and immunologic responses) standardized for several important infectious human diseases.  The infectious diseases phenotyping technological platform is accessible to researchers working in the academic domain using murine models with the intention to increase our comprehension of the predisposition to infection and facilitate the discovery of genes that play a major role in the treatment of infectious diseases.


Pathogenic Agent

Human Disease
Murine model

Bacteria

Bacille Calmette-Guérin (BCG)
Listeria monocytogenes
Used as vaccines 

Listeriosis
Transitory infection 
Acute systemic infection
Salmonella Typhimurium
Salmonella Typhimurium
Salmonella Enteritidis
Citrobacter rodentium
Salmonellosis

Enterocolitis

Salmonellosis

E. coli enteritis
Typhoid fever

Enterocolitis

Chronic carrier

Colon hyperplasia

Virus

Cytomegalovirus (CMV) Immunitary deficiency predisposing to a first infection by the CMV Transitory infection
Coxsackie virus Disease feet-hands-mouth-meningitis, encephalitis, myocarditis  Myocarditis

Parasites

Plasmodium chaubaudi
Leishmania donovani
Leishmania major
Malaria
Visceral leishmaniasis
Cutaneous leishmaniasis
Malaria
Visceral leismaniasis
Cutaneous leishmaniasis

Fungus

Cryptococcus neoformans Brain inflammation Skin, eyes and genital system Brain, spleen, lung infection


Service request

The project manager and organization committee members will act as consultants to guide the researcher for the appropriate phenotyping choice for its project.

For a request, please contact:  info@rrtq.org

Academic Cost

The phenotyping costs vary according to the type of infection.  Phenotyping costs including the collection of tissues and the estimation of the microbial load in the targeted organs are on average of 25$ by mouse for an experience lasting over a period of 2 weeks.  For projects involving a longer time span, a cost of $1 per mouse per day will be added.  The purchase costs of the control animals are excluded.  Additional expenses will apply for any intermediate phenotyping as a result of the required tests and the number of submitted animals.

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